Profil Penggunaan Antibiotik Profilaksis Sectio Caesarea di Rumah Sakit X Jawa Barat
DOI:
https://doi.org/10.37277/sfj.v17i2.2001Kata Kunci:
antibiotik profilaksis, PPAB, PPRA, sectio caesareaAbstrak
Antibiotik profilaksis merupakan antibiotik yang diberikan sebelum, saat dan hingga 24 jam pasca operasi pada kasus yang secara klinis tidak didapatkan tanda-tanda infeksi dengan tujuan untuk mencegah terjadinya infeksi pada luka operasi. Antibiotik profilaksis sectio caesarea (SC) merupakan antibiotik yang diberikan untuk mencegah infeksi pasca SC. Penelitian ini bertujuan untuk mengevaluasi kepatuhan penggunaan antibiotik profilaksis SC terhadap Panduan Penggunaan Antibiotik (PPAB) Rumah Sakit X Jawa Barat khususnya terkait penggunaan antibiotik profilaksis SC. Penelitian ini bersifat kuantitatif deskriptif dengan pengumpulan data bersifat retrospektif. Subjek yang diamati dalam penelitian ini adalah dokumen rekam medis dan buku registrasi pasien SC di Rumah Sakit X Jawa Barat periode semester I tahun 2024. Seluruh pasien SC diinventarisasi mulai dari identitas pasien dan dokter serta penggunaan antibiotik profilaksisnya, yaitu pilihan antibiotik profilaksis, dosis, rute, waktu pemberian serta jumlah pemberian antibiotik profilaksisnya. Didapatkan kepatuhan pemilihan dan pemberian dosis antibiotik profilaksis SC sesuai PPAB rata-rata sebesar 18,97% dan 1,58%, kepatuhan rute pemberian dosis antibiotik profilaksis SC sesuai PPAB 100%, rata-rata kepatuhan pemberian antibiotik profilaksis SC 30-60 menit sebelum tindakan 36,33% dan kepatuhan pemberian antibiotik profilaksis SC dosis tunggal 41,48%. Kepatuhan penggunaan antibiotik profilaksis SC di Rumah Sakit X Jawa Barat sesuai PPAB masih sangat kurang.
Referensi
Akbar, M.I.A., Ulhaq, R.A., Yuliati, I., Yusuf, M., Prasetyo, B., & Tjokroprawiro, B.A. (2023). Penggunaan Antibiotik pada Operasi Sesar oleh Dokter Obstetri dan Ginekologi di Kota Terbesar Kedua di Indonesia. Indonesian Journal of Obstetrics and Gynecology, 11(2), 80-85.
Al-Momany, N.H., Al-Bakri, A.G., Makahleh, Z. M., & Wazaify. M.M.B. (2009). Adherence to international antimicrobial prophylaxis guidelines in cardiac surgery: a Jordanian study demonstrates need for quality improvement. Journal of managed care pharmacy, 15(3), 262-71. doi: 10.18553/jmcp.2009.15.3.262.
American Society of Health-System Pharmacist [ASHP]. (2024). Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Diambil dari https://www.ashp.org/pharmacy-practice/policy-positions-and-guidelines/browse-by-document-type/therapeutic-guidelines?loginreturnUrl=SSOCheckOnly. (diakses pada 31 Mei 2024).
American College of Obstetricians and Gynecologists. (2011). ACOG Practice Bulletin No. 120: Use of prophylactic antibiotics in labor and delivery. 117(6),1472-1483. doi: 10.1097/AOG.0b013e3182238c31.
Berghella, V., Baxter, J.K., & Chauhan, S.P. (2005). Evidence-based surgery for cesarean delivery. American journal of obstetrics and gynecology, 193(5), 1607-17. doi: 10.1016/j.ajog.2005.03.063.
Bratzler, D.W., Dellinger, E.P., Olsen, K.M., Perl, T.M., Auwaerter, P.G., Bolon, M.K., et al. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical infections, 14(1), 73-156. doi: 10.1089/sur.2013.9999. Epub 2013 Mar 5.
Dayana, M., Nurmainah, & Untari, E.K.. (2019). Gambaran Penggunaan Antibiotik Profilaksis pada Pasien Sectio Caesarea di Rumah Sakit Universitas Tangjungpura Tahun 2017. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1), 1-12.
Fanani, Z., Aisah, N., & Ridwana. (2022). Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Operasi Sectio Caesarea di RSU Islam Klaten tahun 2020. Indonesia Jurnal Farmasi, 7(1), 33-37.
Huang, Y., Yin, X., Wang, X., Zhou, F., Cao, X., Han, Y., et al. (2022). Is a single dose of commonly used antibiotics effective in preventing maternal infection after cesarean section? A network meta-analysis. Public Library of Science. doi: 10.1371/journal.pone.0264438. eCollection 2022.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2011). Peraturan Menteri Kesehatan Republik Indonesia No. 2406/MENKES/PER/XII/2011 tentang Pedoman Umum Penggunaan Antibiotika.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2021). Peraturan Menteri Kesehatan Republik Indonesia No. 28 tahun 2021 tentang Pedoman Penggunaan Antibiotika.
Lamfel, R., Snyman, L., Seopela, L., Jahn, G., & Becker, P. (2024). Early online. South African Medical Journal, 114(5), e1081. doi: 10.7196/SAMJ.2024.v114i6.2232.
Makani, M. & Andayani, T.M. (2019). Pengaruh Pemberian Antibiotik Profilaksis Terhadap Infeksi Luka Operasi pada Pasien Bedah Obstetri dan Ginekologi di RSUP Dr. Sardjito. Majalah Farmaseutik, 17(1), 29-37.
Mackeen, A.D., Packard, R.E., Ota, E., Berghella, V., & Baxter, J.K. (2014). Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. The Cochrane database of systematic reviews. doi: 10.1002/14651858.CD009516.pub2.
Moore, J., Navarro, S., McCarthy, K., Rashid, R.B., Phipps, S., Amoako, A., et al. (2023). State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases. Acta Obstetricia et Gynecologica Scandinavica, 102, 811–820. doi: 10.1111/aogs.14577.
Muzayyanah, B., Yulistiani, Y., Hasmono, D., & Wisudani. N. (2018). Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery. Folia Medica Indonesiana, 54(3), 161-166.
Nabhan, A.F., Allam, N.E., & Salama, M.H.A. (2016). Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD011876.pub2.
Nitrushwa, D., Ghebre, R., Unyuzimana, M.A., Magriples U., Small, M., & Rulisa, S. (2021). Single vs. extended antibiotic for prevention of surgical infection in emergent cesarean delivery. International Journal of Pregnancy & Child Birth, 7(2), 51–56.
Oktaviani, F., Wahyono, D., & Yuniarti, E. (2015). Evaluasi Penggunaan Antibiotik Profilaksis terhadap Kejadian Infeksi Luka Operasi pada Operasi Sectio Caesarea. Jurnal Manajemen dan Pelayanan Farmasi, 5(4), 255-258.
Perkumpulan Obstetri Ginekologi Indonesia [POGI]. (2013). Panduan Antibiotik Profilaksis pada Pembedahan Obstetri Ginekologi.
Reiff, E.S., Habib, A.S., Carvalho, B., & Raghunathan, K. (2020). Antibiotic Prophylaxis for Cesarean Delivery: A Survey of Anesthesiologists. Anesthesiology Research and Practice. doi: 10.1155/2020/3741608.
Rumah Sakit X Jawa Barat. (2018). Panduan Penggunaan Antibiotik.
Schalkwyk, J.V. & Eyk, N.V. (2017). Antibiotic Prophylaxis in Obstetric Procedures. Journal of Obstetrics and Gynaecology Canada, 39(9), 293-299. doi: 10.1016/j.jogc.2017.06.007
Smaill, F. & Hofmeyr, G.J. (2002). Antibiotic prophylaxis for cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD000933.
Smaill, F.M. & Grivell, R.M. (2014). Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD007482.pub3.
Viamonte, K.R., Tames, A.S., Correa, R.S., Manteca, M.V.R., & Suárez, A.M. (2021). Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital. Antimicrobial Resistance and Infection Control. 10(1):12. doi: 10.1186/s13756-020-00843-1.
World Health Organization [WHO]. (2021). WHO recommendation on Prophylactic antibiotics for women undergoing caesarean section.
Yeung, J.., Pauls, R., & Crisp, C. (2016). Appropriate Timing of Prophylactic Antibiotics at Cesarean Delivery [23D]. Obstetrics and Gynecology. doi:10.1097/01.AOG.0000483401.02399.0a.
Al-Momany, N.H., Al-Bakri, A.G., Makahleh, Z. M., & Wazaify. M.M.B. (2009). Adherence to international antimicrobial prophylaxis guidelines in cardiac surgery: a Jordanian study demonstrates need for quality improvement. Journal of managed care pharmacy, 15(3), 262-71. doi: 10.18553/jmcp.2009.15.3.262.
American Society of Health-System Pharmacist [ASHP]. (2024). Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Diambil dari https://www.ashp.org/pharmacy-practice/policy-positions-and-guidelines/browse-by-document-type/therapeutic-guidelines?loginreturnUrl=SSOCheckOnly. (diakses pada 31 Mei 2024).
American College of Obstetricians and Gynecologists. (2011). ACOG Practice Bulletin No. 120: Use of prophylactic antibiotics in labor and delivery. 117(6),1472-1483. doi: 10.1097/AOG.0b013e3182238c31.
Berghella, V., Baxter, J.K., & Chauhan, S.P. (2005). Evidence-based surgery for cesarean delivery. American journal of obstetrics and gynecology, 193(5), 1607-17. doi: 10.1016/j.ajog.2005.03.063.
Bratzler, D.W., Dellinger, E.P., Olsen, K.M., Perl, T.M., Auwaerter, P.G., Bolon, M.K., et al. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical infections, 14(1), 73-156. doi: 10.1089/sur.2013.9999. Epub 2013 Mar 5.
Dayana, M., Nurmainah, & Untari, E.K.. (2019). Gambaran Penggunaan Antibiotik Profilaksis pada Pasien Sectio Caesarea di Rumah Sakit Universitas Tangjungpura Tahun 2017. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1), 1-12.
Fanani, Z., Aisah, N., & Ridwana. (2022). Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Operasi Sectio Caesarea di RSU Islam Klaten tahun 2020. Indonesia Jurnal Farmasi, 7(1), 33-37.
Huang, Y., Yin, X., Wang, X., Zhou, F., Cao, X., Han, Y., et al. (2022). Is a single dose of commonly used antibiotics effective in preventing maternal infection after cesarean section? A network meta-analysis. Public Library of Science. doi: 10.1371/journal.pone.0264438. eCollection 2022.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2011). Peraturan Menteri Kesehatan Republik Indonesia No. 2406/MENKES/PER/XII/2011 tentang Pedoman Umum Penggunaan Antibiotika.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2021). Peraturan Menteri Kesehatan Republik Indonesia No. 28 tahun 2021 tentang Pedoman Penggunaan Antibiotika.
Lamfel, R., Snyman, L., Seopela, L., Jahn, G., & Becker, P. (2024). Early online. South African Medical Journal, 114(5), e1081. doi: 10.7196/SAMJ.2024.v114i6.2232.
Makani, M. & Andayani, T.M. (2019). Pengaruh Pemberian Antibiotik Profilaksis Terhadap Infeksi Luka Operasi pada Pasien Bedah Obstetri dan Ginekologi di RSUP Dr. Sardjito. Majalah Farmaseutik, 17(1), 29-37.
Mackeen, A.D., Packard, R.E., Ota, E., Berghella, V., & Baxter, J.K. (2014). Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. The Cochrane database of systematic reviews. doi: 10.1002/14651858.CD009516.pub2.
Moore, J., Navarro, S., McCarthy, K., Rashid, R.B., Phipps, S., Amoako, A., et al. (2023). State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases. Acta Obstetricia et Gynecologica Scandinavica, 102, 811–820. doi: 10.1111/aogs.14577.
Muzayyanah, B., Yulistiani, Y., Hasmono, D., & Wisudani. N. (2018). Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery. Folia Medica Indonesiana, 54(3), 161-166.
Nabhan, A.F., Allam, N.E., & Salama, M.H.A. (2016). Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD011876.pub2.
Nitrushwa, D., Ghebre, R., Unyuzimana, M.A., Magriples U., Small, M., & Rulisa, S. (2021). Single vs. extended antibiotic for prevention of surgical infection in emergent cesarean delivery. International Journal of Pregnancy & Child Birth, 7(2), 51–56.
Oktaviani, F., Wahyono, D., & Yuniarti, E. (2015). Evaluasi Penggunaan Antibiotik Profilaksis terhadap Kejadian Infeksi Luka Operasi pada Operasi Sectio Caesarea. Jurnal Manajemen dan Pelayanan Farmasi, 5(4), 255-258.
Perkumpulan Obstetri Ginekologi Indonesia [POGI]. (2013). Panduan Antibiotik Profilaksis pada Pembedahan Obstetri Ginekologi.
Reiff, E.S., Habib, A.S., Carvalho, B., & Raghunathan, K. (2020). Antibiotic Prophylaxis for Cesarean Delivery: A Survey of Anesthesiologists. Anesthesiology Research and Practice. doi: 10.1155/2020/3741608.
Rumah Sakit X Jawa Barat. (2018). Panduan Penggunaan Antibiotik.
Schalkwyk, J.V. & Eyk, N.V. (2017). Antibiotic Prophylaxis in Obstetric Procedures. Journal of Obstetrics and Gynaecology Canada, 39(9), 293-299. doi: 10.1016/j.jogc.2017.06.007
Smaill, F. & Hofmeyr, G.J. (2002). Antibiotic prophylaxis for cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD000933.
Smaill, F.M. & Grivell, R.M. (2014). Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD007482.pub3.
Viamonte, K.R., Tames, A.S., Correa, R.S., Manteca, M.V.R., & Suárez, A.M. (2021). Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital. Antimicrobial Resistance and Infection Control. 10(1):12. doi: 10.1186/s13756-020-00843-1.
World Health Organization [WHO]. (2021). WHO recommendation on Prophylactic antibiotics for women undergoing caesarean section.
Yeung, J.., Pauls, R., & Crisp, C. (2016). Appropriate Timing of Prophylactic Antibiotics at Cesarean Delivery [23D]. Obstetrics and Gynecology. doi:10.1097/01.AOG.0000483401.02399.0a.
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2024-09-13
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Hasanah, K. (2024). Profil Penggunaan Antibiotik Profilaksis Sectio Caesarea di Rumah Sakit X Jawa Barat. SAINSTECH FARMA, 17(2), 80–87. https://doi.org/10.37277/sfj.v17i2.2001
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