Senyawa Bioaktif dari Tanaman sebagai Kandidat Terapi Gangguan Spektrum Autisme
Keywords:
antioxidant, autism, traditional medicine, neurotransmitter, herbalAbstract
Indonesia has the second largest natural resources in the world. This literature study is intended to summarize the use of herbal and traditional medicines in the treatment of autism in additional therapy. Medicinal plants that are effective for autism show strong antioxidant activity combined with anti-inflammatory activity and effects on neurotransmitters. The study was conducted using a literature study method using the Pubmed, Google Scholar, and Science Direct databases and using different combinations of keywords autism, ASD, herbal, traditional plant, neutrotransmitter. The results of a review of several articles indicate that pegagan, ginko biloba, and ginseng plants have potential as candidate therapies for ASD patients. Plants as traditional medicine and important sources of modern pharmaceutical compounds have great potential in supporting well-being and managing complex symptoms in people with autism.
References
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Omar, N. S., Akmal Che Zakaria, Z., Sue Mian, T., Zurinah Wan Ngah, W., Mazlan, M., Raja Muda Abdul Aziz, J., & Lumpur, K. (2011). Centella asiatica modulates neuron cell survival by altering caspase-9 pathway. Journal of Medicinal Plants Research, 5(11), 2201–2109. http://www.academicjournals.org/JMPR
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Cruz-Martins, N., Quispe, C., Kirkin, C., Şenol, E., Zuluǧ, A., Özçelik, B., Ademiluyi, A. O., Oyeniran, O. H., Semwal, P., Kumar, M., Sharopov, F., López, V., Les, F., Bagiu, I. C., Butnariu, M., Sharifi-Rad, J., Alshehri, M. M., & Cho, W. C. (2021). Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder. Oxidative Medicine and Cellular Longevity, 2021, 1. https://doi.org/10.1155/2021/1131280
Devarkar, V. D. (2025). Traditional Herbal Approaches to the Management of Autism Spectrum Disorder (ASD): A Review. Plantae Scientia, 8(1), 9–14. https://doi.org/10.32439/ps.v8i1.9-14
Hasanzadeh, E., Mohammadi, M. R., Ghanizadeh, A., Rezazadeh, S. A., Tabrizi, M., Rezaei, F., & Akhondzadeh, S. (2012). A double-blind placebo controlled trial of ginkgo biloba added to risperidone in patients with autistic disorders. Child Psychiatry and Human Development, 43(5), 674–682. https://doi.org/10.1007/s10578-012-0292-3
Kardani, A., Soltani, A., Sewell, R. D. E., Shahrani, M., & Rafieian-Kopaei, M. (2019). Neurotransmitter, Antioxidant and Anti-neuroinflammatory Mechanistic Potentials of Herbal Medicines in Ameliorating Autism Spectrum Disorder. Current Pharmaceutical Design, 25(41), 4421–4429. https://doi.org/10.2174/1381612825666191112143940
Mansor, N. I., Ling, K. H., Rosli, R., Hassan, Z., Adenan, M. I., & Nordin, N. (2023). Centella asiatica (L.) Urban. Attenuates Cell Damage in Hydrogen Peroxide-Induced Oxidative Stress in Transgenic Murine Embryonic Stem Cell Line-Derived Neural-Like Cells: A Preliminary Study for Potential Treatment of Alzheimer’s Disease. Journal of Alzheimer’s Disease, 94(s1), S21–S44. https://doi.org/10.3233/JAD-221233
Orhan, I. E. (2012). Centella asiatica (L.) Urban: From traditional medicine to modern medicine with neuroprotective potential. Evidence-Based Complementary and Alternative Medicine, 2012. https://doi.org/10.1155/2012/946259
Orouji, N., Karimi, M., Sadat-Shirazi, M. S., & Zargaran, A. (2024). A Narrative Review of Effective Herbal and Traditional Medicines on Management of Autism. Traditional and Integrative Medicine, 9(4), 478–487. https://doi.org/10.18502/tim.v9i4.17480
Rossignol, D. A., & Frye, R. E. (2014). The use of medications approved for Alzheimer’s disease in autism spectrum disorder: A systematic review. Frontiers in Pediatrics, 2(AUG). https://doi.org/10.3389/fped.2014.00087
Sachdeva, P., Mehdi, I., Kaith, R., Ahmad, F., & Anwar, M. S. (2022). Potential natural products for the management of autism spectrum disorder. Ibrain, 8(3), 365–376. https://doi.org/10.1002/ibra.12050
Saki, K. (2018). Autism: Synthetic-and plant-derived control and treatment. International Journal of Green Pharmacy, 12(3), 483–489.
Sevindik, M., Mohammed, F. S., & Uysal, I. (2023). Autism: plants with neuro-psychopharmacotherapeutic potential. Prospects in Pharmaceutical Sciences, 21(3), 38–48. https://doi.org/10.56782/pps.143
Omar, N. S., Akmal Che Zakaria, Z., Sue Mian, T., Zurinah Wan Ngah, W., Mazlan, M., Raja Muda Abdul Aziz, J., & Lumpur, K. (2011). Centella asiatica modulates neuron cell survival by altering caspase-9 pathway. Journal of Medicinal Plants Research, 5(11), 2201–2109. http://www.academicjournals.org/JMPR
Sivamaruthi, B. S., Suganthy, N., Kesika, P., & Chaiyasut, C. (2020). The role of microbiome, dietary supplements, and probiotics in autism spectrum disorder. International Journal of Environmental Research and Public Health, 17(8). https://doi.org/10.3390/ijerph17082647
Wanasuntronwong, A., Tantisira, M. H., Tantisira, B., & Watanabe, H. (2012). Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice. Journal of Ethnopharmacology, 143(2), 579–585. https://doi.org/10.1016/j.jep.2012.07.010
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Published
2025-11-13
How to Cite
Wenas, D. M. (2025). Senyawa Bioaktif dari Tanaman sebagai Kandidat Terapi Gangguan Spektrum Autisme. Sainstech Farma: Jurnal Ilmu Kefarmasian, 18(1), 37–46. Retrieved from https://journal.istn.ac.id/index.php/saintechfarma/article/view/2358
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