Evaluation of Antihypertensive Use in Pregnant Women with Preeclampsia at RSUD Kabupaten Bekasi in 2024

Authors

  • Hilda Hermawati ISTN
  • Tahoma Siregar Institut Sains dan Teknologi Nasional
  • Rodhiyatul Fithri Institut Sains dan Teknologi Nasional

Keywords:

antihypertention, drug usage evaluation, preeclampcia

Abstract

Hypertension was one of the common health problems that occurred during pregnancy, with one of its complications being preeclampsia. Preeclampsia was a major cause of maternal and fetal morbidity and mortality, and its prevalence in Indonesia remained quite high, including in Bekasi Regency. The management of preeclampsia included the rational use of antihypertensive drugs to reduce the risk of eclampsia. This study aimed to describe patient demographics, the profile of antihypertensive use, and to evaluate the appropriateness of antihypertensive use in pregnant women. The results of this study showed that the use of antihypertensive drugs in pregnant women with preeclampsia at RSUD Bekasi Regency in 2024 was dominated by single therapy with methyldopa (73.33%), followed by combinations of methyldopa with nifedipine (21.67%), methyldopa with amlodipine (3.33%), and single nifedipine (1.67%). The evaluation of appropriateness showed that the right patient, indication, drug, and dosage each reached 100%. The use of antihypertensive drugs in pregnant women with preeclampsia at RSUD Bekasi Regency was generally rational according to therapeutic standards, in terms of drug selection, dosage, as well as suitability for patient and indication.

 

References

Ardhany, S. D. (2019). Gambaran Penggunaan Obat Antihipertensi pada Pasien Preeklampsia di Instalasi Rawat Inap Rumah Sakit Bhayangkara Kota Palangka Raya Tahun 2016. Jurnal Surya Medika, 4(2), 17–25. https://doi.org/10.33084/jsm.v4i2.541

Awaludin, A., Nurzaman, M. H., Annisa, & Herdianti, N. (2023). Hubungan Penggunaan Kombinasi Antihipertensi Dengan Luaran Neonatal pada Pasien Preeklamsia. MPI (Media Pharmaceutica Indonesiana), 5(2), 156–164. https://doi.org/10.24123/mpi.v5i2.6072

Badan Pusat Statistik. (2023). “Cerita Data Statistik Indonesia Edisi 2024.01.” 94.

Dinkes kabupaten Bekasi. (2022). Profil Kesehatan Kabupaten Bekasi 2022. In Dinas Kesehatan Kabupaten Bekasi.

Dinkes Provinsi Jawa Barat. (2023). Profil Kesehatan Jawa Barat 2023. Dinas Kesehatan Provinsi Jawa Barat, 1–294.

Dipiro, J. T., Reams, N., & Beltran, E. (2008). Pharmacotherapy Handbook 7th Edition. In The Youth Athlete: A Practitioner’s Guide to Providing Comprehensive Sports Medicine Care. https://doi.org/10.1016/B978-0-323-99992-2.00076-1

Dwi, K. A., Sayyidah, & Kuswara, S. R. (2024). Evaluasi rasionalitas penggunaan obat antihipertensi pada ibu hamil dengan preeklampsia di instalasi rawat inap di rsu kota tangerang selatan. In Prosiding Semlitmas (Seminar Hasil Penelitian Dan Pengabdian Masyarakat), 1(1), 319–329.

Friska Adelia S, Jangga, J., & Kurnia Anjani, Q. (2024). Evaluasi Efektivitas Penggunaan Obat Antihipertensi Pada Pasien Preeklampsia Rawat Inap Di RSIA Sitti Khadijah 1 Makassar. Jurnal Farmasi Galenika, 11(2), 94–107. https://doi.org/10.70410/jfg.v11i2.336

Hasimun, P., & Sukmawati, I. K. (2024). Analisis Penggunaan Obat Antihipertensi pada Ibu Hamil di Rawat Inap RS Bandung. In Bakti Tunas Husada Conference Series, 4, 36–46.

Karmelita, D. M. (2020). Efektivitas Nipedipin Sebagai Tokolitik Dalam Persalinan Prematur. Jurnal Kedokteran STM (Sains Dan Teknologi Medik), 3(2), 49–58. https://doi.org/10.30743/stm.v3i2.54

Kasriatun, K., Kartasurya, M. I., & Nugraheni, S. A. (2019). Faktor Risiko Internal dan Eksternal Preeklampsia di Wilayah Kabupaten Pati Provinsi Jawa Tengah. Jurnal Manajemen Kesehatan Indonesia, 7(1), 30–38. https://doi.org/10.14710/jmki.7.1.2019.30-38

Kemenkes RI. (2021). Buku Saku Merencanakan Kehamilan Sehat. In Kementrian Kesehatan RI.

Kundarto, W., & Faizah, R. N. (2021). Evaluasi Terapi Antihipertensi Pada Pasien Preeklampsia Berat di Instalasi Rawat Inap RSUD Dr. Moewardi Periode Januari - Juni Tahun 2017. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 6(2), 228. https://doi.org/10.20961/jpscr.v6i2.39487

Ndwiga, C., Odwe, G., Pooja, S., Ogutu, O., Osoti, A., & Warren, C. E. (2020). Clinical presentation and outcomes of preeclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study. PLoS ONE, 15(6 June), 1–15. https://doi.org/10.1371/journal.pone.02333 23

Nirupama, R., Divyashree, S., Janhavi, P., Muthukumar, S. P., & Ravindra, P. V. (2021). Preeclampsia: Pathophysiology and management. Journal of Gynecology Obstetrics and Human Reproduction, 50(2), 101975. https://doi.org/10.1016/j.jogoh.2020.101975

Nurizawati, Nurmainah, & Purwanti, N. U. (2018). Profil Penggunaan Antihipertensi Pada Pasien Pre-eklampsia di Rumah Sakit Umum Yarsi Pontianak Tahun 2018. Jurnal Mahasiswa Farmasi Fakultas Kedokteran Untan, 4(1), 1–16.

POGI. (2016). PNPK Diagnosis dan Tatalaksana Preeklampsia. 1–48.

QCG, Guidelines, Queensland, & Clinical. (2021). Maternity and Neonatal Clinical Guideline Hypertension and pregnancy. Queensland Health, No. MN21.13-V9-R26, 1–39.

Ramadhani, G. (2023). Evaluasi Penggunaan Antihipertensi dan Faktor Risiko Pada Ibu Hamil Preeklampsia di Rumah Sakit Fatmawati Jakarta Selatan Tahun 2021. Jurnal Farmasi Klinik Base Practice, 2(2), 46–64. https://doi.org/10.58815/jfklin.v2i2.30

Rana, S., Lemoine, E., Granger, J., & Karumanchi, S. A. (2019). Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation Research, 124(7), 1094–1112. https://doi.org/10.1161/CIRCRESAHA.118.313276

Rezaei, Z., Sharbaf, F. R., Pourmojieb, M., Youefzadeh-Fard, Y., Motevalian, M., Khazaeipour, Z., & Esmaeili, S. (2011). Comparison of the efficacy of nifedipine and hydralazine in hypertensive crisis in pregnancy. Acta Medica Iranica, 49(11), 701–706.

Santika, M., Damayanti, E., & Sukohar, A. (2024). Tatalaksana Hipertensi Pada Kehamilan. Asep Sukohar ‫|‬ Review Artikel : Tatalaksana Hipertensi Pada Kehamilan Medula |, 14, 934.‬‬‬‬‬‬‬‬‬‬‬‬‬

Yani, Y. A., Oktavia, N., & Rame, M. M. T. (2021). Evaluasi Penggunaan Obat Antihipertensi Pasien Preeklampsia di Instalasi Rawat Inap RSUD Prof. Dr. W.Z Johannes Kupang. CHM-K Pharmaceutical Scientific Journal, 4(1), 242–248.

Yin, J., Mei, Z., Shi, S., Du, P., & Qin, S. (2022). Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. Arch Gyenecol, 6. https://doi.org/10.1007/s00404-022-06504-5

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Published

2026-07-29